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Conditions A-Z

Major depressive disorder

From Wikidata and MedlinePlus; a guide, not a diagnosis.

Usual symptoms

  • Low mood with loss of interest, poor sleep or appetite for two weeks or more
  • Low mood most days
  • Losing interest or pleasure in things
  • Tiredness that rest does not fix
  • Trouble falling or staying asleep
  • Loss of appetite
  • Weight loss without trying
  • Irritability
  • Trouble thinking, planning or concentrating
  • Thoughts of ending your life
  • Sadness

Red ones can be signs of an emergency: get help at once.

Having some of these does not mean you have this condition: many conditions share the same symptoms.

Who to see

  • A mental health worker or psychiatrist

Risk factors listed

substance abuse, family medical history, chronic condition

Related health checks

Mood check (PHQ-9) · Worry and anxiety check (GAD-7) · Signs to talk over with a specialist

Read more

  • Depression MedlinePlus
    What is depression?Depression is more than a feeling of being sad or irritable for a few days. It's a serious mood disorder. As one of the most common mental disorders in the United States, depression can affect how you think, feel, and yo…
  • Seasonal Affective Disorder MedlinePlus
    Seasonal affective disorder (SAD) is a type of depression that comes and goes with the seasons. It usually starts in the late fall and early winter and goes away during the spring and summer. Some people do have episodes of depression that…
  • Postpartum Depression MedlinePlus
    What is postpartum depression?Having a baby can be exciting, but it can also be stressful and bring many strong emotions. During the postpartum period, which is the time after you give birth, you may have mood swings, crying spells, or fee…

Search MedlinePlus for “Major depressive disorder” · Symptom guide · Health checks

Symptoms, specialties, risk factors and codes from Wikidata (CC0 public domain); reading from MedlinePlus, U.S. National Library of Medicine. A guide, not a diagnosis: please see a health worker.